Versão integral disponível em digitalis.uc escreve: não se …
seguintes fenómenos: acessos narcolépticos, sonolên- cia. perturbações psíquicas limitadas à esfera emotiva, moral e afectiva. A esfera intelectual estava intacta. Feito o diagnóstico do tumor da região infundíbulo-tu- beriana, foi confirmado pela terapêutica. Radioterapia penetrante. Cura. Observações análogas de perturbações …
Identifying what makes a neuron fire
With a fresh appreciation that sensory systems promote survival by extracting behaviourally relevant information about important (positive or negative) events in the surrounding world, in the last 20 or so years neuroscientists have begun to apply 'naturalistic stimuli': stimulus sets that contain innately meaningful features, for instance …
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The Phase of Oscillation in Cortical Network and Its …
stimulus orientation respectively. Besides, 𝐹. 𝑚𝑎𝑥. is maximal firing rate. The connections between Poisson groups andorientation columns are forward and unidirectional, all the havingsame
Frontiers | Dissociable effects of dopamine on neuronal firing rate …
Previous studies showed that dopamine depletion leads to both changes in firing rate and in neuronal synchrony in the basal ganglia. Since dopamine D1 and D2 receptors are preferentially expressed in striatonigral and striatopallidal medium spiny neurons, respectively, we investigated the relative contribution of lack of D1 and/or D2-type …
Neuronal firing rates diverge during REM and homogenize …
Introduction. Firing rates vary among neurons and across time. The dynamic range of a neuron's firing is determined by a combination of membrane geometry, distribution and subtypes of ion channels, and synaptic efficacy 1 – 6.Changes in these properties can potentially alter a neuron's gain function or "excitability", altering the …
Simulation constants. | Download Table
Second, neurons in the cortex typically have graded firing rates, with each neuron having an approximately exponential distribution of firing rates to a set of stimuli 3,4,22,23 .
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Validation of a non-invasive, real-time, human-in-the-loop
Objective: Despite the tremendous promise of invasive brain-computer interfaces (iBCI), the associated study costs, risks, and ethical considerations limit the opportunity to develop and test the algorithms that decode neural activity into a user's intentions. Our goal was address this challenge by designing an iBCI model capable of testing many human subjects in …
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Intrinsic firing patterns of diverse neocortical neurons
Neurons of the neocortex differ dramatically in the patterns of action potentials they generate in response to current steps. Regular-spiking cells adapt strongly during maintained stimuli, whereas fast-spiking cells can sustain very high firing frequencies with little or no adaptation. Intrinsically bursting cells generate clusters of spikes ...
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The firing activity of pyramidal neurons in medial prefrontal …
The changes in the firing rate and firing pattern of pyramidal neurons in medial prefrontal cortex (mPFC) and the effects of selective 5-hydroxytryptamine-(1A) (5-HT(1A)) receptor agonist (R)-(+)-8-hydroxy-2-(dipropylamino)tetralin hydrobromide (8-OH-DPAT) and antagonist N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-2 …
Dissociation between sustained single-neuron spiking and
Determining the relationship between single-neuron spiking and transient (20 Hz) β-local field potential (β-LFP) oscillations is an important step for understanding the role of these oscillations in motor cortex. We show that whereas motor cortex firing rates and beta spiking rhythmicity remain sust …
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Rapid and active stabilization of visual cortical firing rates
The dynamics of neuronal firing during natural vision are poorly understood. Surprisingly, mean firing rates of neurons in primary visual cortex (V1) of freely behaving rodents are similar during prolonged periods of light and darkness, but it is unknown whether this reflects a slow adaptation to changes in natural visual input or insensitivity to rapid changes in …
Quantitative firing pattern phenotyping of hippocampal …
Two-step cluster analysis identified ten firing pattern families as leaves of a seven-level hierarchical binary tree (Fig. 4a ). At the highest level, hippocampal neuron types and subtypes are ...
Distributed representations of temporal stimulus associations …
The prefrontal cortex has been implicated in various cognitive processes, including working memory, executive control, decision making, and relational learning. One core computational requirement underlying all these processes is the integration of information across time. When rodents and rabbits a …
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Deciphering functional roles of synaptic plasticity and
Neural systems in many species comprise of different neural circuits (Beierlein, 2003) and their connection and function are highly experience-dependent.The specific period during early development after eye opening for mice at postnatal day P14-P20 to the critical period(CP) onset (P20-21) involves changes of the intrinsic neuronal …
Persistent hippocampal neural firing and hippocampal …
Task and behavior. Subjects performed a modified Sternberg WM task (36 total sessions from nine subjects). The task differs from the original Sternberg paradigm in that the items were presented all at once rather than sequentially, thus separating the encoding period from the maintenance period.
Persistent hippocampal neural firing and hippocampal
ORCIDs linked to this article. Fedele T, 0000-0001-7574-8062 Hilfiker P, 0000-0001-7729-4754, Swiss Epilepsy Clinic at Clinic Lengg AG Sarnthein J, 0000-0001-9141-381X, Universitat Zurich Boran E, 0000-0002-0395-7575, Klinik für Neurochirurgie, UniversitätsSpital und Universität Zürich, Switzerland Stieglitz L, 0000-0002-3744-5105, …
Prefrontal Cortex HCN1 Channels Enable …
In many cortical neurons, HCN1 channels are the major contributors to Ih, the hyperpolarization-activated current, which regulates the intrinsic properties of neurons and shapes their integration of …
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